Advanced Glycation Endproducts


AGEs play a pivotal role in the development of chronic age-related diseases such as diabetes, renal failure and cardiovascular disease.

Measuring AGEs

Until now it has been complicated to measure tissue AGEs in patients because existing methods are expensive, time consuming, lack specificity, are poorly reproducible and/or are invasive.


The AGE Reader is the answer to the need for measuring AGEs without the disadvantages of the existing methods. This state of art device provides a simple non-invasive solution which allows clinicians to determine the AGE level within 12 seconds.


Many advanced glycation endproducts (AGEs) have a characteristic fluorescence. Moreover, tissue fluorescence in (invasive) biopsies has an established association with chronic complications. The AGE Reader is able to easily, quickly and noninvasively measure this tissue fluorescence.

The AGE Reader has a light source which illuminates the tissue of interest. This light excites fluorescent moieties in the tissue which will emit light with a different wavelength. In the used wavelength band the major contribution in fluorescence comes from fluorescent AGEs. The emitted light is detected using a spectrometer or photodiodes. By using specific technical adaptations including selection of specific wavelength, modulated or pulsed light sources, a more selective discrimination of specific AGEs can be obtained.


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AGE Reader mu
Non-invasive cardiovascular risk assessment
The AGE Reader mu is the next generation AGE Reader that combines a high measurement quality standard with an innovative design, at a reduced price level. The AGE Reader mu is a perfect tool for diabetologists and family doctors.
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Information about Advanced Glycation Endproducts, the AGE measurement and clinical validation.