Advanced Glycation Endproducts


AGEs play a pivotal role in the development of chronic age-related diseases such as diabetes, renal failure and cardiovascular disease.

Accumulation of AGEs

AGEs accumulate over a person’s lifetime, but this process occurs more rapidly in patients with conditions such as diabetes mellitus, renal failure and cardiovascular disease. Accumulation of AGEs is an important factor in the development of chronic complications of these conditions. Tissue AGEs correlate closely with early kidney, eye and nerve disease in patients with diabetes mellitus. Moreover they are valuable predictors of future cardiovascular morbidity and mortality.

Diagram - Creation of AGEs from Glucose

Once accumulated AGEs will stay in the tissue for a long time. This is largely detemined by the lifetime of the protein to which the AGEs are cross-linked. The lifetimes of proteins in tissue are easily up to several years meaning that accumulated AGEs are expected to stay in the tissue for years. Due to this, new drugs aimed at preventing breaking and formation of AGEs are currently in (late) clinical development.


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AGE Reader mu - connect
Non-invasive cardiovascular risk assessment
The AGE Reader provides an immediate prediction for the cardiovascular risk of your patient. The non-invasive and extensively validated AGE Reader is and ideal tool for point of care testing. The measurement result is available in 12 seconds and can be exported directly.
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