Advanced Glycation Endproducts

AGEs

AGEs play a pivotal role in the development of chronic age-related diseases such as diabetes, renal failure and cardiovascular disease.

AGE Interventions

Lifestyle

AGEs are endogenously formed in the human body, but this process also occurs in preparing foods and drinks at all temperatures. The higher the heat however, and the longer the time food is heated the greater the formation of AGEs. Fried and processed foods are therefore typically high in AGEs.

Detailed information and videos about AGEs in food can be found on NutritionFacts.

Lifestyle interventions consist of dietary programs and physical exercise. As a result of increased physical exercise, glycemic control is known to improve and lead to weight loss. There are dietary programs available that are specifically focused on managing the dietary intake of AGEs. Furthermore, it has already been shown in scientific studies that substantial physical exercise is associated with lower levels of tissue AGEs.

Pharmaceutical

Drugs targeting AGEs or AGE-pathways have already been in development for a number of years. One of these drugs targeting the AGE-pathway is Azeliragon (TTP488). This drug was developed by vTv Therapeutics for the treatment of Alzheimer’s disease. Additionally, Azeliragon (TTP488) is an orally bioavailable small molecule that inhibits the receptor for advanced glycation endproducts (RAGE). 

Dietary supplements

Taking dietary supplements is a popular method to manage and lower AGE levels in tissues. Multiple companies are working on new dietary supplements to manage AGEs and some already have products on the market. An example of one such company is Morinda (USA), who has developed several beverages and gels to manage AGE levels.

Skincare

As AGEs lead to the wrinkling of skin, they are an important target for the skin care industry. Most of the large international cosmetic companies have already developed creams and capsules targeting AGEs in the skin.

 

Measuring AGEs

More Information
Request information

Would you like to learn more about our products? Request any information you wish to receive here.

Video
AGE Reader mu
Non-invasive cardiovascular risk assessment
The AGE Reader provides an immediate prediction for the cardiovascular risk of your patient. The non-invasive and extensively validated AGE Reader is and ideal tool for point of care testing. The measurement result is available in 12 seconds and can be exported directly.
Read more »
About the company

More information about Diagnoptics.

Information for patients

Information on Diagnoptics' products and Advanced Glycation Endproducts.

Information for professionals

Information about Advanced Glycation Endproducts, the AGE measurement and clinical validation.