Advanced Glycation Endproducts


AGEs play a pivotal role in the development of chronic age-related diseases such as diabetes, renal failure and cardiovascular disease.

Advanced Glycation Endproducts

In 1912 Louis-Camille Maillard, a French chemist, conducted a simple experiment in his lab that turned out to be a shortcut that created meat flavor and aroma through heating sugar and amino acids. This chemical reaction has thus been called Maillard Reaction or Browning Reaction. Following extensive research on the Maillard Reaction across diverse fields from food, nutrition to therapeutics, the term Advanced Glycation Endproducts or AGEs was introduced to describe the end products of the Maillard Reaction that are formed under normal physiological conditions in living organisms.
AGEs are also externally formed by the heating of food and are taken up by the body when this food is ingested. Examples of food with very high level of AGEs are cola and creme brulee. Another source of AGEs intake is due to smoking.

Until now it has been complicated to measure tissue AGEs in patients because existing methods are expensive, time consuming, lack specificity, are poorly reproducible and/or are invasive. The AGE Reader is the answer to the need for measuring AGEs without the disadvantages of the existing methods. This state of art device provides a simple non-invasive solution which allows clinicians to determine the AGE level within 12 seconds.

Many advanced glycation endproducts (AGEs) have a characteristic fluorescence. Moreover, tissue fluorescence in (invasive) biopsies has an established association with chronic complications. The AGE Reader is able to easily, quickly and noninvasively measure this tissue fluorescence.

Read more about the accumulation of Advanced Glycation Endproducts
Wikipedia Advanced Glycation Endproducts
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AGE Reader mu
Non-invasive cardiovascular risk assessment
The AGE Reader mu is the next generation AGE Reader that combines a high measurement quality standard with an innovative design, at a reduced price level. The AGE Reader mu is a perfect tool for diabetologists and family doctors.
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