AGEs are dangerous compounds that formed through non-enzymatic glycation
AGEs build up silently in the body, driving aging and
chronic disease.
About AGEs
Invisible drivers of aging
and disease
Advanced Glycation End-products (AGEs) are invisible molecules that build up silently in the body. They stiffen tissues, damage organs, and accelerate aging, affecting health long before symptoms appear. Diagnoptics has pioneered AGE research for over 20 years, making the invisible visible.
What are AGEs
Sugars that bind
and accumulate
AGEs form when sugars bind to proteins and fats in the body. Over time, these compounds build up in tissues such as blood vessels, organs, and skin. The higher the levels, the more they disrupt balance and speed up biological aging.
Effect of AGEs
Impact on health
and vitality
AGE accumulation leads to stiffer blood vessels, premature skin aging, and higher risk of chronic conditions like diabetes, kidney disease, and cardiovascular problems.
The science behind AGEs
How AGEs harm the body over time
AGEs (Advanced Glycation End-products) are formed when sugars attach to proteins and fats. Over time, they create irreversible crosslinks that stiffen tissues such as blood vessels, skin and organs. AGEs also bind to the RAGE receptor, triggering inflammation and oxidative stress.
Key mechanisms
• Crosslinking: AGEs bond with collagen and elastin,
reducing flexibility and repair capacity.
• Inflammation: Activation of the RAGE receptor triggers
chronic inflammatory pathways.
• Oxidative stress: AGEs amplify free radical activity,
accelerating cellular damage.
Research confirms that these processes accelerate
biological aging and contribute to chronic disease.
Health impact
How AGEs affect the body
Persistent in tissues for years, AGEs offer a unique window into cumulative damage and chronic disease progression.
Vessels & organs
Stiffening, reduced function, higher disease risk. AGEs stiffen blood vessels and organs, reducing elasticity and impairing function, increasing long-term disease risk.
Skin
Faster aging, wrinkles, loss of elasticity. AGEs accelerate skin aging, causing wrinkles, loss of elasticity, and reduced repair capacity.
Chronic diseases
High AGE levels are linked to diabetes complications, kidney disease, cardiovascular conditions, and neurodegeneration.
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