AGE reader validation

Key publications

Hartog J. et al, Transplantation • Volume 87, Number 7, April 15, 2009

Skin-Autofluorescence Is an Independent Predictor of Graft Loss in Renal Transplant Recipients

Lutgers H. et al:Diabetologia, 2009; 52(5): 789-797

Skin autofluorescence provides additional information to the UK Prospective Diabetes Study (UKPDS) risk score for the estimation of cardiovascular prognosis in type 2 diabetes mellitus

Meerwaldt R et al, Diabetologia 2004; 47:1324-1330

Simple non-invasive assessment of advanced glycation endproducts accumulation

Publications

Greven W. et al. BMC Clinical Pathology; 2010: 10 (4)

Accumulation of advanced glycation end (AGEs) products in intensive care patients: an observational, prospective study.

Noordzij M. et al. Diabetes Technol Ther. 2010; 12(7): 581-585

Skin autofluorescence and glycemic variability.

Lutgers H. et al. Eur j Clin Invest. 2010; doi: 10.1111/j.1365-2362.2010.02329.x

Carotid artery intima media thickness associates with skin autofluoresence in non-diabetic subjects without clinically manifest cardiovascular disease.

Koetsier M. et al. Optics Express, Vol 18 No. 14

Skin color independent assessment of aging using skin autofluorescence

Tanaka K. et al. Nephrol Dial Transplant. doi: 10.1093/ndt/gfq369

Skin autofluorescence is associated with renal function and cardiovascular diseases in pre-dialysis chronic kidney disease patients.

Ueno H et al. Metabolism, 2010, doi: 10.1016/j.metabol.2010.04.001

Advanced glycation end products, carotid atherosclerosis, and circulating endothelial progenitor cells in patients with end-stage renal disease.

Koetsier M. et al. Diabetes Technology & Therapeutics 2010; 12(5):399-403.

Reference Values of Skin Autofluorescence.

Hartog J. et al; Eur. Journal of Heart Failure

Advanced glycation end-products, anti-hypertensive treatment and diastolic function in patients with hypertension and diastolic dysfunction.

Chabroux S. et al: Diabetes Metab, 2010, doi:10.1016/j.diabet.2009.11.003

Advanced glycation end products assessed by skin autofluorescence in type 1 diabetics are associated with nephropathy, but not retinopathy.

McIntyre et al; CJASN, doi: 10.2215/CJN.05350709

Tissue-Advanced Glycation End Product Concentration in Dialysis Patients

Mulder D. et al: Netherlands Heart Journal, Volume 17, Number 4, April 2009

Skin autofluorescence is elevated in acute myocardial infarction and is associated with the one-year incidence of major adverse cardiac events.

Sachithanandan et al; Poster at American Diabetes Association 2007

Increased Tissue Fluorescence in Type 1 Diabetes Complications and Inverse Relationships with Vascular Elasticity and Glucose Disposal Rate

Smit et al, ATTD, Athens, 26-28 February 2009

NONINVASIVE SKIN AUTOFLUORESCENCE, AN INDEPENDENT PREDICTOR OF COMPLICATIONS IN DIABETES, ITS RELATION TO GLYCEMIC VARIABILITY

Jochemsen M. et al: Journal of Food and Nutrition Research Vol. 48, 2009, No. 1, pp. 51–58

Relation between food and drinking habits,and skin autofluorescence and intima media thickness in subjects at high cardiovascular risk

Koetsier M. et al: Optics Express; 19 Jan. 2009

Skin autofluorescence for the risk assessment of chronic complications in diabetes: a broad excitation range is sufficient

Ueno H. et al: Metabolism Clinical and Experimental 57 (2008) 1452–1457

Skin autofluorescence, a marker for advanced glycation end product
accumulation, is associated with arterial stiffness in patients with
end-stage renal disease

Nienhuis H. et al: Rheumatology 2008: doi:10.1093/rheumatology/ken302

Skin autofluorescence is increased in systemic lupus erythematosus but not reflected by plasma levels advanced glycation endproducts

Hartog J. et al: Journal of Cardiac Failure, 2008: in press

Skin autofluorescence, a measure of tissue advanced glycation endproducts, is related to the distolic function of dialysis patients

Gerrits et al, Journal of Diabetes Science and Technology 2008: Volume 2, Issue 4, July

Skin Advanced Glycation Endproducts Accumulation is Poorly Reflected by Glycemic Control in Type 2 Diabetic Patients

Stirban A et al, Diabetes Technology & Therapeutics 2008: volume 10 number 3

Skin autofluorescence increases postprandially in human subjects

Hartog J et al, European Heart Journal 2007:28, 2878-2885

Clinical and prognostic value of advanced glycation endproducts in chronic heart failure

de Leeuw et al, Rheumatology 2007:46:1551-1556

Accumulation of advanced glycation end products in patients with systemic lupus erythematosus

Matsumoto et al - Rheumatol Int. 2007 Dec 28(2): 157-60.

Measurement of advanced glycation endproducts in skin of patients with rheumatoid arthritis, osteoarthritis, and dialysis-related spondyloarthropathy using non-invasive methods.

Gerrits E et al - Diabetes Care Nov 2007

Skin Autofluorescence: A tool to identify type 2 diabetic patients at risk for developing microvascular complications

Hartog J. et al - AHA 2007

Advanced Glycation Endproducts (AGEs), as measured by Skin-autofluorescence, are strongly and independently related to dystolic function in dialysis patients

Gerrits E. et al - EASD 2007

Increased skin autofluorescence: a more pronounced marker of mortality in hemodialysis patients than diabetes mellitus?

Kampinga MA. et al - IMARS 2007

Skin autofluorescence as marker of AGE accumulation in acute coronary syndrome

Monami M. et al. Diabetes Research & Clinical Practice July 2007: 2007.07.007

Skin autofluorescence in type 2 diabetes: Beyond blood glucose

Kampinga MA. et al - IMARS 2007

Autofluorescence as marker of AGE accumulation in acute infectious disease

Mulder DJ, et al. IMARS 2006

Skin Autofluorescence, a Non-invasive Marker for Advanced Glycation End products is increased in patients with Age related Macular Degeneration.

Mulder DJ, et al. AGE meeting, Cambridge Mass, March 2006

Oral intake of a single meal high in AGE content results in enhanceds skin autofluorescence in healthy subjects.

Lutgers HL, et al. EASD 2006

Skin AGE-levels are increased in type 2 diabetes mellitus with complications

Mulder DJ, et al. AHA 2005

Skin Autofluorescence Predicts One Year Incidence of Major Adverse Cardiac Events after Acute Myocardial Infarction.

Lutgers HL, et al. Journal of the American Society of Nephrology 2003; 14:397A.

Skin age levels as a marker of renal complications in type 2 diabetes mellitus.

Mulder DJ, et al. Eur Soc Intensive Care Medicine 2004

Enhanced skin autofluorescence as a marker for oxidative stress in sepsis, a pilot study.

Lutgers HL, et al. IDF 2003/Diabetologia 2003; 46:A404.

AGE accumulation is poorly reflected by long term metabolic control in Type 2 diabetic patients.

Mulder DJ, et al. IMARS 2006

Exogenously derived advanced glycation endproducts and progression of skin autofluorescence in subjects at high risk for cardiovascular disease

Mulder DJ, et al. IMARS 2006

The Influence of Exogenously Derived Advanced Glycation End products on the 15 Months Progression of Skin Autofluorescence in Subjects at High Risk for Cardiovascular Disease.

Mulder DJ, et al. AHA 2006

Skin autofluorescence predict one year incidence of major adverse cardiac events after acute myocardial infarction

Meerwaldt R, et al. BMSA 2003

Skin autofluorescence in diabetes mellitus: Noninvasive measurement of advanced glycation endproducts accumulation

Blaauw J. et al.Am J Obstet Gynecol. 2006 Sep;195(3):717-22.

Skin autofluorescence, a marker of advanced glycation end products and oxidative stress, is increased in recently preeclamptic women.

Smit AJ, Lutgers HL.Curr Med Chem. 2004 Oct;11(20):2767-84.

The clinical relevance of advanced glycation endproducts (AGE) and recent developments in pharmaceutics to reduce AGE accumulation.

Mulder DJ. et al. Cardiovasc Drugs Ther. 2007 Apr;21(2):91-7.

The Effect of Aggressive Versus Conventional Lipid-lowering Therapy on Markers of Inflammatory and Oxidative Stress.

Mulder DJ. et al. Atherosclerosis. 2007 May 11.

Skin autofluorescence is elevated in patients with stable coronary artery disease and is associated with serum levels of neopterin and the soluble receptor for advanced glycation end products.

den Hollander NC. et al. J Inherit Metab Dis. 2007 Jun 14.

Advanced glycation end products and the absence of premature atherosclerosis in glycogen storage disease Ia

Lutgers HJ. et al. American Diabetes Association 2007, Poster

Skin Autofluorescence is Additive to the UKPDS Risk-score in the Prediction of Cardiovascular Complications in Type 2 Diabetes

Gerrits ES. et al. American Diabetes Assoication 2007, Poster

Skin Autofluorescence: a Tool to Identify Type 2 Diabetic Patients at Risk for Developing Retinopathy or Neuropathy

Hartog JW. Et al. Ann N Y Acad Sci. 2005 Jun;1043:299-307.

Accumulation of advanced glycation end products, measured as skin autofluorescence, in renal disease.

Meerwaldt R, et al. Ann N Y Acad Sci. 2005;1043:290-298.

Simple noninvasive measurement of skin autofluorescence.

Graaff R et al, Proc. of SPIE Vol. 5692 (SPIE, Bellingham, WA, 2005). pp. 111-118.

Instrumentation for the measurement of Autoflurescence in the human skin

Meerwaldt R, et al. Diabetes Care 2007, 30: 107-112

Skin autofluorescence is a strong predictor of cardiac mortality in diabetes

Meerwaldt R, et al. J Am Soc Nephrol 2005;16:3687-93.

Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation endproducts, predicts mortality in hemodialysis patients.

Hartog J. et al. Am J Kidn Dis 2004; 43:966-975

Advanced glycation endproducts in kidney transplant patients: a putative role in the development of chronic renal transplant dysfunction.

Hartog J. et al. Ann NY Acad Sci 2005;1043:299-307.

Accumulation of Advanced Glycation End Products, Measured as Skin Autofluorescence in Renal Disease.

Mulder DJ, et al. Diabetes Technology and Therapeutics 2006, in press.

Skin Autofluorescence, a Novel Marker for Glycation and Oxidative Stress derived Advanced Glycation Endproducts. An Overview of Current Clinical Studies, Evidence and Limitations.

Mulder DJ. et al. Atherosclerosis 2007, in press.

Skin Autofluorescence is a Non-invasive Marker for Inflammatory Stress in Stable Coronary Artery Disease.

Mulder DJ, et al. Circulation, AHA 2005 abstract.

Skin Autofluorescence is an independent marker for Acute Myocardial Infarction.

Hartog JWL, et al. Nephrol Dial Transpl 2006;epub.

Risk factors for chronic transplant dysfunction and cardiovascular disease are related to accumulation of advanced glycation end-products in renal transplant recipients.

Lutgers H, et al. Diabetes Care. 2006 Dec;29(12):2654-9

Skin autofluorescence as a noninvasive marker of vascular damage in patients with type 2 diabetes.

Meerwaldt R, et al. Diabetologia. 2005;48:1637-44.

Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy.