Advanced Glycation Endproducts

AGEs

AGEs play a pivotal role in the development of chronic age-related diseases such as diabetes, renal failure and cardiovascular disease.

Effects of AGEs

Health related effects
AGEs play a pivotal role in the development of chronic age-related diseases such as diabetes, renal failure and cardiovascular disease. The level of AGEs in long-lived tissues (not in blood!) serves as a memory of glycometabolic and oxidative stress and is a valuable predictor of cardiovascular complications.

The graphic below shows how AGEs can lead to the development of vascular complications through 2 pathways: binding to the receptor of AGEs and cross-linking to proteins. 
 
The figure above not only shows cardiovascular disease and diabetic complications as effects of AGEs, but also CNS disorders. AGEs are thought to play an important role in the plaque formation in neurodegenerative disorders such as Alzheimer's disease.
 
Recently it has been found that AGEs are also associated with worse bone strength. This could be caused by the accumulation of AGEs in bone collagen. 
 

Skin related effects
AGEs accumulate in the whole body including the skin. Cross-linking of AGEs to proteins such as collagen and elastin leads to damaging these proteins. This will lead to the development of wrinkles and a lack of elasticity and eventually leads to an older appearance. A nice overview of the effects of AGEs on skin can be found here. 

There are numerous cosmetic products available that specifically target the accumulation of AGEs in the skin. 

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AGE Reader mu
Non-invasive cardiovascular risk assessment
Age Reader MU
The AGE Reader mu is the next generation AGE Reader that combines a high measurement quality standard with an innovative design, at a reduced pricelevel. The AGE Reader mu is a perfect tool for diabetologists and family doctors.

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