1995
| Dr. Smit and his co-workers made a coincidental finding of increased autofluorescence of the skin in many diabetes patients when they were performing fluorescein capillary leakage studies in diabetes.
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1996
| Dr. Smit and Dr. Graaff developed dedicated prototypes to assess skin autofluorescence in human
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1998
| The first clinical studies in diabetes and renal failure were started with an advanced prototype of the AGE Reader™ in the University Hospital Groningen, the Netherlands
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1999
| Filed patent application for the AGE Reader and published the first scientific report on the clinical use of AGE Reader™ prototype in diabetic patients
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2000
| Initiated the first large scale follow-up study in the Zwolle region
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2003
| Dr. Smit and Dr. Graaff founded DiagnOptics in Groningen, the Netherlands
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2004
| The first clinical study on AGE Reader™ were published in Diabetologia
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2005
| AGE Reader™ was first shown to future users (EASD, Athens 2005)
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| 2006 | AGE Reader™ received CE approval for commercialization in Europe
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| 2009 | AGE Reader CU (Compact Unit) received CE approval
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2010
| DiagnOptics received ISO 13485 certification for its Quality Management System
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